PF-03715455

$1,495.00

$1495/2mg
CAT Number: I008658
CAS Number: 1056164-52-3
Molecular Formula: C35H34ClN7O3S2
Molecular Weight: 700.27
Purity: 98%

Category: Research Chemicals

Description
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PF-03715455（Cat No.:I008658）is a small-molecule drug candidate developed by Pfizer, known primarily as a potent and selective antagonist of the prostaglandin D₂ receptor 2 (DP2, also known as CRTH2). This receptor plays a key role in inflammatory processes, particularly in allergic and respiratory conditions such as asthma and allergic rhinitis. PF-03715455 inhibits DP2-mediated chemotaxis and cytokine release from Th2 cells, eosinophils, and basophils, helping reduce airway inflammation. Its favorable oral bioavailability and selectivity make it a promising therapeutic agent for modulating immune responses in chronic inflammatory diseases with Th2-skewed pathology.

CAS Number	1056164-52-3
Synonyms	PF-03715455; PF 03715455; PF03715455; PF-3715455; PF 3715455; PF3715455.;1-(3-(tert-butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea
Molecular Formula	C35H34ClN7O3S2
Purity	98%
Documentation	CoA-1056164-52-3-M23X08028_2916.pdf
Target	p38 MAPK 14 Inhibitor
Appearance	Solid powder
IUPAC Name	1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea
InChI	InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)
InChIKey	VGEXRDWWPSGZDH-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=NN(C(=C1)NC(=O)NCC2=CC=CC=C2SC3=CN4C(=NN=C4C5=CC=CC=C5SCCO)C=C3)C6=CC(=C(C=C6)O)Cl
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